Senior Principal Scientist - ADME/DMPK

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Date: May 14, 2019

Location: Slough, GB

UCB is a fast-moving global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases affecting the immune and central nervous systems. With more than 7,700 people in approximately 40 countries, the company generated revenue of € 4.2 billion in 2016. UCB invests more than 25% of revenue in cutting-edge scientific research with the objective of solving unmet patient needs. We have a passionate, long-term commitment to the discovery and development of innovative medicines that transform the lives of people with severe diseases.


We are looking for enthusiastic and talented professionals who thrive on challenge and change, who want to make a difference and deliver results.


An important part of our philosophy is to take a holistic approach to patients, which aims to find solutions tailored to their circumstances. By considering patients’ individual characteristics and lifestyles, such as age, diet, family history and genetic profile, we are also coming closer to providing personalized therapies.


This position is a scientific and strategic position in the Global iADME group, which is a part of Development Sciences at New Medicines, UCB, Slough, UK. The Senior Principal Scientist is an individual contributor role reporting directly to Head of Global iADME.


The ideal candidate thrives in a collaborative work environment and is skilled at working for multiple projects concurrently along the full value chain from early discovery to post marketing. In addition, the candidate will be a highly motivated individual who leads and enjoys having broad responsibilities and opportunities as well as being able to provide clear scientific and strategic direction, including novel methodologies and platforms using state of the art technologies for the assessment of ADME properties of our pipeline.


The main initial responsibilities will be a focus on developing in vitro and in vivo models to (i) understand and predict human metabolic/non-metabolic clearance for projects in UCB therapeutic areas Immunology & Bone and Neurology, and (ii) assess and predict the pharmacokinetics of NCEs targeting the CNS, to support the Neuroscience portfolio. These responsibilities requires knowledge in both metabolic and non-metabolic elimination pathways as well as interpreting results for strategic translation from preclinical animal knowledge to humans.


The role also requires awareness of national/international regulatory principles and guidelines regarding assessment of ADME/DMPK properties of molecules to ensure an effective planning, performance and interpretation of regulatory ADME studies in close collaboration with Clinical pharmacology during the late stage projects and post-marketing.


Overall scope of the role:


  • Being a leader of ADME/DMPK science in Slough, UK, by ensuring delivering of scientific DMPK insights in a timely manner, to the portfolio of UCB via a platform of innovative and flexible iADME assays.
  • Coach junior staff to foster a highly innovative mindset and guide development of new assays, being a role model for scientific excellence
  • Build an open, honest, and collaborative relationships within and outside the iADME/DMPK function
  • Increase ADME/DMPK visibility (internally & externally) by demonstrating scientific excellence and credibility, representing UCB in conferences, act as committee member on external scientific boards and organizations and engage in collaborations with academic institutions
  • Show ability to champion and develop new scientific or process strategic directions
  • Act as project representative (ADME representative or expert) along the value chain, and ensure appropriate expertise and data is provided
  • Interact with and influence key collaborators/stakeholders and leaders across New Medicines for an overall understanding of the science needed to progress the UCB pipeline
  • Contribute to submission documents
  • Be an active member of the Global iADME leadership team.


Job Description:


  • Direct projects in science, as an expert for in vitro and in vivo ADME studies
  • Propose and evaluate innovative technologies, techniques, study designs or equipment.
  • Ensure quality and timely delivery of the project deliverables
  • Ensure the scientific quality and expertise of the Global iADME group.
  • Proactive in science and project meetings with scientific input, solutions, and alternative approaches picked up from literature.
  • Champion and develop new scientific strategic directions within ADME/DMPK area
  • Keep abreast of literature; interact with peers in the ADME/DMPK scientific arena.
  • Publish and/or present at conferences on a regular basis.



  • The role requires a PhD (or equivalent) degree in Pharmaceutics, Pharmacology, Drug metabolism & Pharmacokinetics or related areas, with considerable years of Post-doctoral and/or Industrial experience


Experience :

  • The role requires a documented track record of considerable years’ experience, around in vitro and in vivo DMPK and excellent knowledge in ADME and to be able to couple data to optimization/selection of NCE, both in discovery and development
  • In-depth knowledge of ADME scientific area and proactively can propose new development in tools or study designs
  • Knowledge of the full drug development processes in Pharma Industry environment. 
  • Compelling communication and collaborative skills together with a driving performance and a decisive way of acting are necessary abilities in a creative and team oriented working environment
  • Good intercultural understanding.
  • Demonstrated strong and mature leadership and influencing skills
  • Good intercultural understanding.

Job Segment: Scientific, Neurology, Genetics, Immunology, Scientist, Engineering, Healthcare, Science

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