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Let's push the boundaries together and make the most of your talents!

Senior Principal Scientist CADD 1


Anderlecht, Brussels, Belgium

Job Function:  Research & Early Development
Job ID:  70927

Help us transform patients' lives.

At UCB, we put our heart, soul and skills into making a difference for people living with significant unmet needs. Working together, we blend the best of our talents to deliver thoughtful solutions that patients value. Will you join us in this pioneering adventure?





UCB, headquartered in Belgium, is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions for people living with severe diseases of the immune system and the central nervous system. With more than 7,500 people in approximately 40 countries, the company generated revenue of € 4.5 billion in 2017. UCB, recently recognized as the best employer at the Cogent Life Science Awards, invests more than 23% of its revenue in R&D. At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” The connection to patients offers new perspectives, drive innovation, and enable us to deliver solutions that are helping to transform their lives.

We are seeking a recognized scientific leader to join our Computer-Aided Drug Design (CADD) team to advance the discovery of new therapeutic candidates using targeted protein degradation (TPD). The Senior Principal Scientist CADD position can be based in our US research site in Bedford, MA, or in Braine l'Alleud in Belgium and is expected to collaborate effectively with our other research sites in the US, the UK, and Belgium.


You will contribute by: 

•    Independently designing and executing computational experiments in a timely manner to enable the progression of TPD therapeutic projects.
•    Proactively thinking of ways to enhance delivery to the TPD projects. Able to foresee resource requirements and bottlenecks and propose solutions.
•    Creating effective working relationships within the TPD team and beyond via influencing and networking.
•    Championing continuous optimization of drug discovery processes. Effectively solicits input and feedback and drives innovation.
•    Contributing to CADD technology acquisition, development, implementation and applications to pipeline projects through effective project management and cross-functional collaboration.
•    Acting as an ambassador for CADD by providing scientific expertise / leadership at cross-disciplinary meetings and departmental meetings.
•    Understanding UCB R&D strategy and contributes to its implementation. Acts as advisor and driver of change with senior management.
•    Demonstrating strategic thinking for project delivery, identification and implementation of the next disruptive technology within UCB in order to stay at the forefront of drug discovery.


Interested? For this position, you’ll need the following education, experience and skills

Minimum Qualifications:

•    10+ years of drug discovery experience, including therapeutic project leadership roles.
•    PhD in Chemistry, Computational Chemistry, Molecular Modeling or a related field is required with a good publication/patent track record.


Preferred Qualifications:

•    Expert knowledge in structure-based and ligand-based small molecule drug design.
•    Good knowledge in medicinal chemistry.
•    Ability to influence and impact beyond immediate area of responsibility.
•    Ability to communicate effectively in English, both verbally and in writing. 
•    Experience in targeted protein degradation is desired but not required.


Why you should apply:

Do you want to contribute in bringing real value to patients living with severe diseases while driving innovation forward? 
Join UCB’s dynamic, inspiring and innovative environment. You will be recognized for impactful performance via a competitive compensation and benefits package and you will enjoy ample personal development opportunities.


Tell us what makes you the perfect match to our team and join one of the most dynamic & forward-looking organizations in the world. 
To apply, please go to www.ucb.com/careers.  



About Us

At UCB, we come together every day to work, laser-focused, on a simple question: How will this create value for people living with severe diseases? By putting patients at the heart of everything we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees worldwide operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases. We are looking for people with passion and empathy who develop a real understanding of patient’s needs and can deliver thoughtful solutions to decisionmakers across the heath care ecosystem.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. We do not discriminate on the basis of race/color/religion/sex/national origin/veteran/disability/age/sexual orientation/gender identity.

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