Principal Scientist - DEL Chemist

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Date: May 1, 2019

Location: Boston, Massachusetts, US

Principal Scientist –  Chemist for DNA-encoded Libraries

We are seeking a scientific leader and synthetic chemist experienced in the generation and application of DNA-encoded libraries to join our research group in Bedford, MA.


The Organization
UCB is a fast-moving global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases affecting the immune and central nervous systems. With more than 7,700 people in approximately 40 countries, the company generated revenue of € 4.2 billion in 2016. UCB invests more than 25% of revenue in cutting-edge scientific research with the objective of solving unmet patient needs. We have a passionate, long-term commitment to the discovery and development of innovative medicines that transform the lives of people with severe diseases. At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

Role Overview

The successful applicant will demonstrate excellent scientific judgement and be a recognised expert in the field of DNA-encoded libraries with a proven track record and in-depth knowledge of the area. She/He will be instrumental in establishing a DNA-encoded library platform with the clear objective to design and build high-quality libraries as an important part of the overall lead generation strategy at UCB. The role will require extensive collaboration with scientists across our research sites and with external collaborators and CROs.


Primary roles and responsibilities

  • A key contributor to UCB’s DNA-encoded library platform strategy and its implementation.
  • Lead the chemistry efforts to design DNA-encoded libraries by working with internal and external collaborators
  • Execute the acquisition and/or synthesis of those libraries through internal and external partners.
  • Work closely with cheminformaticians to analyze screening data and triage hits.
  • Lead hit validation and hit to lead activities with both internal and external resources as appropriate.
  • Collaborate with external groups for the development of novel DNA compatible reactions to expand the diversity of libraries.
  • Serve as a scientific leader and expert in DNA-encoded libraries and provide recommendations regarding emerging external capabilities.
  • Ensure optimal interaction/communication and provide updates on project status to Chemistry leadership


Candidate requirements and qualifications

  • A PhD in synthetic organic chemistry or a related field is required.
  • In depth knowledge and 5 years’ hands-on experience in all aspects of the DEL platform, including library design, synthesis, data analysis, hits selection and validation, is required.
  • Track record of successful delivery of compound libraries and/or chemistry technology platforms, utilizing internal and external resources, is highly desired.
  • Experience with modern chemoinformatics, computational tools and scientific software in drug discovery is desired.
  • Strong track record of scientific publications and patent applications.
  • The ideal candidate will create effective working relationships in a matrix environment. She/he will also demonstrate a high level of entrepreneurship and foster can-do and can-win attitude. Very good knowledge of verbal and written English is essential.


Interested individuals should apply online on UCB website and include the following items:

1. A cover letter outlining research interests and experience as well as career goals

2. Curriculum Vitae

3. Expected availability

Job Segment: Chemist, Chemistry, Organic Chemistry, Scientific, Scientist, Science, Engineering

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