Senior Principal Research Scientist - CADD

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Date: Mar 18, 2019

Location: Boston, Massachusetts, US

We are seeking an exceptional candidate to join our Computer-Aided Drug Design (CADD) team within Global Chemistry to drive the discovery of new therapeutic candidates using targeted protein degradation. 

Company Overview

UCB, headquartered in Belgium, is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions for people living with severe diseases of the immune system and the central nervous system. With more than 7,500 people in approximately 40 countries, the company generated revenue of € 4.5 billion in 2017. UCB, recently recognised as the best employer at the Cogent Life Science Awards, invests more than 23% of its revenue in R&D. At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” The connection to patients offer new perspectives, drive innovation, and enable us to deliver solutions that are helping to transform their lives.

Job Accountabilities

Independently design and execute computational experiments in a timely manner to drive the application of targeted protein degradation technology to therapeutic projects.

Be proactive in anticipating project needs, contributing strategy and driving project progression from target evaluation to lead-optimisation.

Drive innovation and new technology, bringing in external science and methodology and developing new ways of working internally at UCB.

Contribute to scientific discussions and present data at internal meetings and external scientific conferences.

Contribute to the maintenance of a safe and effective working environment by setting high personal standards and complying with all Company HSE codes of practice.

Create effective working relationships within the global chemistry and UCB matrix working environment via influencing and networking.

Demonstrate high level of entrepreneurship and foster a can-do and can-win attitude.

Drive own professional development for continuous improvement of knowledge and skills. Mentor less experienced colleagues. Help to create a teamwork environment.

The candidate

Minimum requirements: -

A PhD in molecular modelling or a related field is required with a good publications track record.

Experience of structure-based or ligand-based small molecule design.

Experience in programming languages such as C++ and/or Python.

Ability to communicate effectively in English, both verbally and in writing, and skilled in communicating scientific concepts through data visualization.

Desired skills and experience: -

Experience in drug-ability and target evaluation.

Experience in targeted protein degradation.

Application of advanced statistics.

Knowledge of advanced molecular simulations approaches (examples of these packages are AMBER, GROMACS, ACEMD, NAMD, SIRE, Plumed, Desmond) and examples of applications to protein-ligand and protein-protein binding.

Development of advanced cheminformatics protocols using KNIME/PipelinePilot or coding toolkits such as RDkit, CDK or OpenEye.

Understanding of modern medicinal chemistry.

Familiarity with screening and assay design.

Job Segment: Chemistry, Scientific, Research Scientist, Scientist, Science, Engineering, Research

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