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Research Scientist - Targeted Protein Degradation


Boston, Massachusetts, United States

Job Function:  Research & Early Development
Job ID:  65198

Research Scientist – Targeted Protein Degradation

UCB Biosciences

Bedford, MA (Greater Boston Area)


Help us transform patients’ lives.

At UCB, we put our heart, soul and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in our pioneering adventure?


Job Summary  

We seek a lab-based research scientist with responsibility for the development and prosecution of cellular and in vitro assays to support drug discovery in targeted protein degradation.

Targeted protein degradation (TPD) is an exciting new small-molecule modality that will expand the target portfolio and a key investment for UCB. As a lab-based research scientist in our team, you will responsible for developing cell-based and other in vitro assay systems to facilitate the identification and optimization of small molecule degraders. The position requires hands-on experience with cell-based assay development and troubleshooting. You will work closely with our scientists across multiple departments and multiple research sites.


Major Accountabilities

  • Development and execution of assays to evaluate targeted protein degradation including assessment of target and E3 ligase biology, ubiquitin proteasome pathway, protein dynamics and downstream function in disease relevant assays.
  • Lab based scientist responsible for assay development and biochemical data to successfully progress drug discovery projects under aggressive timelines.
  • Drive implementation of technology developments assisting the understanding of the molecular mechanisms of potential therapeutics.
  • Provide strong scientific thinking, develop hypotheses and drive scientific learnings on projects.
  • Ensure impactful project contributions through effective internal and external collaboration.

Education and Qualification

  • BSc/MSc in biological sciences.
  • 4-6 years of applicable research experience (industry preferred), with excellent scientific track record.
  • Ability to execute independently with little direction but also to thrive in a multidisciplinary team environment.
  • Experience of applying cellular and biochemical techniques for target validation, drug discovery screening and evaluating the mechanism of action of novel molecular entities.
  • Experience in the independent design, development, optimization and prosecution of a range of in vitro cell-based assays.  This will include experience in data handling and analysis.   
  • Experience in biochemical approaches, and cell biology techniques including but not limited to binding assays, protein complementation assays, and protein:protein interaction assays. 
  • Experience with lab automation.

Desirable skills

  • Experience with the ubiquitin-proteasome pathway including monitoring the ubiquitin-proteasome and autophagy systems and protein-protein interaction complex dynamics are a plus.
  • Neuroscience and/or immunology background is a plus.
  • Understanding of protein biochemistry and characterization.
  • Experience with small molecules/ligands/therapeutics in a pharma/biotech environment.

Job Segment: Research Scientist, Scientific, Neurology, Biochemistry, Immunology, Science, Engineering, Healthcare

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