Senior Research Scientist

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Date: Jan 19, 2019

Location: Boston, Massachusetts, US

 

Senior Research Scientist -  Functional Biology                                                                                                                                                                                                                                                                                                                                                                                                                                                            Targeted Protein Degradation

Bedford, MA

 

The Organization:

UCB is a fast-moving global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases affecting the immune and central nervous systems. With more than 7,700 people in approximately 40 countries, the company generated revenue of € 4.2 billion in 2016. UCB invests more than 25% of revenue in cutting-edge scientific research with the objective of solving unmet patient needs. We have a passionate, long-term commitment to the discovery and development of innovative medicines that transform the lives of people with severe diseases. At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.  

 

Primary Responsibilities of the Position:

  • Design and execution of molecular biology and CRISPRa/i/KO approaches to evaluate targeted protein degradation including assessment of target and E3 ligase abundance, ubiquitin proteasome pathway activities, complex protein dynamics and downstream phenotypes.
  • Design and development of lentiviral screening libraries and other high throughput screening libraries, advanced cell culture techniques including culturing a wide variety of human cell lines.
  • Accountability for achieving project milestones and delivering on objectives.
  • Drive scientific excellence and technology evaluations to maximize impact on the program and projects.
  • Drive implementation of technology developments assisting the understanding of the molecular mechanisms of potential therapeutics.
  • Provide strong scientific thinking, develop hypotheses and drive scientific learnings on projects.
  • Ensure impactful project contributions through effective internal and external collaboration.

Education and Experience:

Essential Requirements

  • PhD in applicable field.
  • 3-5 years of applicable research experience, with excellent scientific track record. 
  • Proven excellence and direct experience of the design, development, optimization and prosecution of applying molecular and CRISPRa/i/KO techniques for target validation, drug discovery screening and evaluating the mechanism of action of novel molecular entities.
  • Experience with the analysis and statistics relevant to in vitro screens.  Experience with relevant software tools, and automation is a must. 
  • Experience in advanced molecular biology and cell culture techniques including advanced cloning techniques and culturing a wide variety of human cell lines.  Experience with gene editing and molecular biology is a must.
  • Experience with small molecules/ligands/therapeutics is a necessity.
  • Excellent communicator, with good presentation and organizational skills.
  • Ability to work independently but also to thrive in a multidisciplinary team environment.

Desirable Requirements

  • Experience with the ubiquitin-proteasome pathway including monitoring the ubiquitin-proteasome and autophagy system and protein-protein interaction complex dynamics are a plus.
  • Neuroscience and/or immunology background is a plus.
  • Experience in the use of proteomic techniques for measuring changes in protein expression, post-translational modification and protein-protein interactions.
  • Understanding of protein biochemistry, recombinant proteins and tagging schemes and protein biophysical characterization.
  • Background with proteomics a plus.


Job Segment: Biochemistry, Neurology, Scientific, Research Scientist, Science, Engineering, Healthcare, Research

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