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Gene Therapy Molecular Biology Expert


Braine L'alleud, Walloon Brabant, Belgium

Job Function:  Clinical Development
Job ID:  66668

Gene Therapy CMC Development Sciences

Location: Braine L'alleud, Walloon Brabant, Belgium


To strengthen our Gene Therapy CMC Development Sciences, based in our hub in Braine, Belgium we are looking for a talented individual to fill the position of: Gene Therapy Molecular Biology Expert.

As a Gene Therapy Molecular Biology Expert, you will identify and foster purposeful partnerships with key scientific influencers to drive new sources of patient value.

You like to work in an environment where you can:

Support the Adeno-Associated Virus (AAV) manufacturing processes and products with the aim of providing treatment to unmet medical needs through gene therapy

Identify and implement high through-put analytical tools supporting the release and stability of multiple therapeutic gene therapy programs throughout clinical phases (from phase 1 readiness to launch)

This is a growth opportunity that combines the excitement and opportunity of a start-up with the security and institution knowledge gained from working for a larger company.

You will contribute by:


  • Supporting release and stability testing of Gene Therapy Products by developing, validating, coordinating, executing and/or tech transferring fast, reliable and QC friendly molecular biology methods
  • Leading assay development, driving results, and onboarding new technologies with minimal supervision
  • Cross-training on and providing support for upstream/downstream operations, In-Process Analysis, characterization and vector biology teams
  • Providing high quality documentation (procedures, protocols, reports) of all technical work performed in the lab in accordance with data integrity requirements
    • Verify data (double check, data check)
    • Participate to the result analysis and trending
    • Present/discuss results in team meetings
  • Preparing written procedures and instructions
  • Sustaining scientifically current (state of the art) laboratory environment and/or data systems
  • Working independently and cross functionally across various UCB teams (medicinal chemists, cell biologists, disease area exerts, antibody engineers, …) and consequently being potentially the GT analytics point of contact to for a considered project
  • Managing priorities, and engaging/communicating in a multidisciplinary environment
  • Supporting the development of the UCB GT strategy through, for example, building internal and external capabilities (i.e. CMOs/CROs).

All these activities will be performed in respect of the material and premises, in compliance with the HSE/Biosafety/GSP or GMP rules and with the regulatory requirements for each development phase of the product.


Interested? For this position you’ll need the following education, experience and skills:


  • Ph.D preferred but Master’s Degree may be sufficient based on experience
  • Understanding of assay development within the biopharmaceutical industry
  • Strong and proven laboratory skills
  • Min 2 years of experience in a GMP regulated laboratory
  • Knowledge of statistical tools supporting the development/characterization of reliable analytical methods
  • Working knowledge of viral biology preferred
  • Ability to operate the following technologies/equipment/software is preferred:
    • Western Blots, ELISA, Gel Electrophoresis, PCR (ideally ddPCR), flow cytometry, electronic lab notebook, …
  • Ability to think critically and demonstrate troubleshooting and problem-solving skills
  • Well organized, flexible, meticulous and rigorous (data integrity oriented)
  • Knowledge and understanding of regulatory requirements and of HSE/Biosafety/GMP-GSP rules
  • Good knowledge of English and ability to read, analyze, and interpret common scientific journals
  • Ability to integrate new concepts and to work in a multicultural environment and to work efficiently and independently in a changing environment.
  • Interpersonal skills to communicate and maintain good working relationships within the team and with internal/external customers/partners
  • Team spirit oriented and able to offer/receive constructive feedbacks


Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.

If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.



Apply now »