Bioprocess Engineer : Tech Transfer & Automation

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Date: Jun 15, 2019

Location: Braine L'alleud, Walloon Brabant, BE

Bioprocess Engineer : Tech Transfer & Automation

Braine l’Alleud, Belgium  

Help us transform patients’ lives. 
At UCB, we put our heart, soul and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in our pioneering adventure? 

To strengthen our team, based in our hub in Braine l’Alleud, Belgium, we are looking to fill the position of: BioProcess Engineer: Tech Transfer & Automation at Biologics Pilot Plant (BPP)

Do you describe yourself as helpful? Are you a futurist? Add these two together and you're a ‘helpfulurist’ at UCB. This unique blend of talent means you are a cooperative forward thinker with patient wellbeing in mind. 

As a UCB 'helpfulurist' and Biologics Pilot Plant Bioprocess Engineer you like to work in an environment where you can:

• Support the biologics manufacturing activities on-going in the facility as well as the manufacturing activities happening at our manufacturing partners facilities. This candidate will be part of the BPP process engineering team.

• With core expertise in bioprocess engineering, you will have special focus (maximum 30% of your time) as super user on automation systems (such as PCS7). You will act as biopilot expert (SME) in execution, troubleshooting & improvement of BPP bioprocess needs via automation

As a UCB 'helpfulurist' and Biologics Pilot Plant Bioprocess Engineer you will contribute by: 
• Performing the transfer of processes from small-scale development units to the pilot plant and from pilot plant to commercial manufacturing sites. (Manufacturing/Process Description, mass balance, end of campaign summary meetings, risk assessment, campaign reports, lessons learnt)

• Acting as BPP automation bioprocess expert user. This means being responsible as BPP point of contact super user to support primarily Zeta & PCS7 and to a later stage other automation tools (e.g. UniCorn)

• Supporting manufacturing teams by being a process and process equipment expert; taking part / leading troubleshooting challenges faced during the execution of process, in compliance with cGMP rules.

• Leading the design of new – or modified process equipment, (re-) qualification of equipment,  (re-) validation.

• Driving/Supporting continuous improvements of equipment, systems and methods to increase UCB’s Biologics Pilot Plant efficiency.

• Setting-up and improving process monitoring, data management and process learning, identify, develop and implement potential process improvements..

• Working closely with other SMEs to standardize operational practices and monitoring among the different areas/scales.  

• Leading deviations (Creation, Root Cause assessment, Impact Analysis, CAPA definition and execution, investigations) and change controls (new process introduction, technical modifications of the facilities)

• Mentoring and supervising junior process engineers as well as colleagues inside & outside the group. 
 Interested? For this position you’ll need the following education, experience and skills
• MSc level of education in process or bioprocess engineering or biotechnology with 3-5 years of experience in running, designing or supporting cell-based manufacturing activities of biologic drug substance.

• Sound knowledge of technologies and unit operations involved in (upstream and/or downstream) bioprocessing.

• Able to understand/master various automation technologies (Zeta, Siemens, Unicorn…), their functional specifications and their architecture.

• Practical experience with technology transfers, scale-up and optimization of processes.

• Track record of defining/leading/coordinating specific projects.

• Continuous improvement mind-set and experience with lean manufacturing initiatives.

• Experience of equipment qualification/validation, including URS creation and qualification execution.

• Good quality understanding in GMP-related environment.

• Excellent communication skills, as interacting with different teams/stakeholders: operators, production managers, process development scientists; equipment and material vendors, production QA representatives, maintenance, metrology…

• Fluent in French and English, both spoken and written.

• Team player, and experienced to work interactively with various stakeholder and under limited supervision.

• Excellent time-management skills, and experienced to work pro-actively to achieve given milestones and objectives. Able to work with time pressure.

• Proven capability to act in complex and high pace projects and environments.


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