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Let's push the boundaries together and make the most of your talents!

Upstream Manager


Braine L'alleud, Walloon Brabant, Belgium

Job Function:  Business Development
Job ID:  66138

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

AT UBC, we recently announced the consturction of an innovative and environmentally sustainable multi-product manufacturing facility on our site in Braine l'Alleud. This new biotechnology plant is being constructed to accompany the company's growth strategy and to prepare for the launch and for the long-term supply of future medicines that are currently in clinical development. This aims to contribute directly to drive our global ambition of improving the life of patients suffering from rare diseases.



The new facility, representing an investment of more than 300 million euros over the coming years, is expected to be operational in 2024. Construction is due to start in the first quarter of 2020. The biotechnology plant will be one of the largest and most modern in Belgium. 



We are now looking for talented, inspired, daring and engaged individuals who share our ambition to create value for patients and who want to be part of our journey to prepare for the next biopharmaceutical product launches. 


In this context, we want to strengthen the team in charge of the project deployment and to start-up these future manufacturing activities: we are looking for an Upstream Manager.



As an Upstream Manager you will be part of our Braine Technical Operations department and be involved in the design and qualification of the equipment and production areas as well in the set up the organizational and technical structure of the new Biotech Manufacturing plant in close collaboration with the Head of Biotech Manufacturing Braine.


You like to work in an environment where you can:


  • Be a pillar in all project phases from Detailed Design to equipment qualification, to achieve the defined project objectives timely and qualitatively
  • Act as USP area client representative during the duration of the project, within the UCB project team and towards the engineering contractor and the suppliers
  • Support and control that all activities are performed as planned and ensure significant risks are identified, mitigated and escalated as appropriate
  • Establish an efficient and robust manufacturing operations process
  • Develop the USP team and organization to be able to support the project efficiently and to move smoothly into manufacturing operations


You will contribute by:


  • Leading and developing the UCB USP team supporting and ensuring that the project key success factors (performance, sustainability, compliance, safety, strategic fit) are embedded into the project design and fulfilled
  • Controlling that activities are performed by the suppliers as stated in the respective contracts
  • Ensuring that significant issues and risks are identified, mitigated and escalated as appropriate
  • Emphasizing an efficient coordination with the engineering company and the suppliers
  • Communicating efficiently the information regarding all other project functions (BU/CU, Infrastructure, C&V, Automation…)
  • Guaranteeing that USP process equipments and operations are designed, installed and qualified as per industrial technical standards, complying with GEP and GMP rules and in a harmonized manner with USP and support equipment
  • Integrating all HSE requirements in all aspects of the projects
  • Supporting the set-up of an efficient process project team organization able to perform the project tasks (design, installation, commissioning, verification) and moving smoothly into an operational mode at end of the project
  • Training the USP team adequately to the required project procedures
  • Ensuring proper and efficient integration of new employee
  • Preparing and supporting the operational start-up of the plant 


Interested? For this position you’ll need the following education, experience and skills:


  • Master’s Degree
  • +8 years of experience in Biotech manufacturing operations and /or related projects
  • Experience in running large scale upstream production suite
    • Strong knowledge of cGMP and HA regulations
    • Ability to construct and develop an agile, skilled and proactive organization
    • Demonstrated leadership skills
    • Ability to work in a highly dynamic environment and to handle challenging situations
    • Excellent communication skills from a leadership, change management & facilitation perspective
    • Decision making ability and high accountability
    • Ability to challenge and argument
  • Ready to travel a limited period of time



Why you should apply ?

Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.


If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.


About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

Job Segment: Neurology, Immunology, Biotech, Engineer, Manager, Healthcare, Science, Engineering, Management

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