Principal Scientist/Senior Scientist Biomarker Immunoassay

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Date: Jul 30, 2019

Location: Slough, Berkshire, GB

Role Overview

The Translational Biomarkers and Bioanalysis group is positioned within the function of Development Sciences, which as a division provides strategy and support in integrated pharmacokinetics/pharmacodynamics and DMPK, bioanalysis, immunogenicity, safety, pathology, and regulatory activities throughout the lifespan of projects, from target identification through to clinical studies. The Translational Biomarkers and Bioanalysis department operate and collaborate closely with colleagues in Development Sciences and across the organization to support bioanalysis and biomarker activities.

 

The Biomarker Immunoassay Group within Translational Biomarkers and Bioanalysis is looking for high caliber, self-motivated, lab-based candidates with a strong scientific background, good written and verbal communication skills and who can multi-task effectively and adapt to meet the demands of a fast-paced matrix-team environment.

 

The role is based in Slough, UK.

 

Primary Responsibilities

  • You will employ your expertise for the development of complex biomarker assays for measuring analytes in biofluids and tissue samples exploring diverse approaches to ensure delivery of high-quality fit-for-purpose assays
  • Using in-house developed or commercially available immunoassays to measure the levels of biomarkers and biologic drug candidates
  • Assessment of novel biomarkers to ensure right dose, right molecule and right patient population within future clinical trials
  • Where appropriate, characterize antibodies, conduct reagent evaluation and perform reagent qualification assays
  • Provide in-depth knowledge of assay development and troubleshoot technical challenges across multiple platforms
  • Provide the appropriate levels of assay quality to ensure fit for purpose use
  • Work within the Bioanalytical area to optimize experimental design, troubleshooting, sample analysis, data interpretation and report generation
  • You will have in-depth knowledge of bioanalytical tools to provide scientific and technical input to Project teams, Biomarker teams and Development Sciences teams
  • Liaise with statistics and bioinformaticians to ensure optimum design of experiments
  • Ensure compliance with all health and safety regulations
  • Work within collaborations with external partners, academic institutions, CROs and consultants as required
  • Maintain an awareness of new / emerging techniques and tools relevant to the field
  • Represent and align with the objectives of Development Sciences internally and externally in matters relevant to biomarkers and bioanalysis

 

Essential Requirements

  • The Applicant should have minimum of BSc (or equivalent) in a biological discipline
  • Extensive expertise with development of ligand binding assays/immunoassays
  • Experience of immunoassays, including but not limited to ELISA, MSD, high sensitivity platforms such as Singulex, Simoa/Quanterix.
  • Proven track record of developing novel fit for purpose biomarker assays from first principles for pre-clinical and clinical assessments.
  • Experience with the appropriate biomarker assay validation towards supporting clinical assessments and knowledge of the latest regulatory standards
  • Clear grasp of context of use (linking assay requirements to the usage of the data generated)
  • A keen understanding of the impact of biological and assay variability for fit for purpose biomarker assay development and data interpretation and proven expertise in delivery
  • Demonstrated ability to work effectively in a dynamic laboratory environment to project timelines with minimal supervision
  • An ability to work in a matrix and communicate clearly to colleagues and project scientists, able to discuss ideas, provide constructive challenge and useful feedback.
  • Adaptable to changing project and organizational priorities and consistently aligned with departmental needs 
     

Desired Skills and Experience

 

  • Previous experience of working in a pharmaceutical drug discovery and assay development environment.
  • Experience working with a wide range of internal stakeholders including Therapeutic Area, Non-Clinical Safety, DMPK, Translational Medicine, Clinical Pharmacologists, Clinical operations and Quality Assurance colleagues.
  • The analysis of pharmacokinetic and pharmacodynamic endpoints
  • Experience of working with electronic lab notebooks
  • Knowledge of statistical tools for the analysis of assays

 

Please ensure to submit your application by Friday 26th July 2019

 


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