Associate Director or Principal Scientist Nonclinical PK-PD NBE

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Date: Jun 29, 2019

Location: Slough, Berkshire, GB

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

 

Role Overview

The Non-Clinical PKPD group sits within the recently formed Quantitative Pharmacology-DMPK function of Development Sciences.  Our goal is to use integrated quantitative approaches as an essential strategic driver from target to market to bring differentiated solutions to patients.  We are driving the quantitative integrated strategy of pharmacokinetics and pharmacology (e.g. PKPD, Systems modelling and clinical pharmacology/pharmacometrics) together with DMPK activities throughout the entirety of the lifetime of projects, from target identification through to life cycle management. We operate and collaborate closely with colleagues in Development Sciences, which, as a department, is responsible for providing strategy and support in bioanalysis, immunogenicity, safety, pathology, and regulatory activities.

 

Our group has a current vacancy where we are looking for an enthusiastic, communicative, matrix-team operational individual with Preclinical PKPD experience to join us.

 

Primary Responsibilities

  • Develop and drive the nonclinical PKPD strategy for projects. Communicate this effectively ensuring implementation in projects.
  • Ensure translation from in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients
  • Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build a thorough knowledge of drug pharmacology and PKPD, leading to quantitative translation to the clinic
  • Build PKPD models of sufficient complexity to allow hypothesis testing and inform decision-making.
  • Provide scientific and technical input, expertise and leadership to Non-clinical PKPD group, project teams, and Development Sciences (Dev Sci)
  • Work within collaborations with external partners, academic institutions, CROs and consultants as required.
  • Maintain an awareness of new / emerging techniques and tools relevant to the field.
  • Represent the interests of Dev Sci internally and externally in matters relevant to mechanistic PKPD and contribute to enhancing the scientific reputation of Non-Clinical PKPD, Dev Sci and UCB.
  • As required, contribute to Due Diligence of external project, product and technology opportunities.
  • Provide required support and input into regulatory study protocols, reports and summaries, and regulatory submission documents.

 

Essential Requirements

  • PhD in relevant discipline (pharmacology, bioengineering, pharmacokinetics/pharmacodynamics, etc.)
  • Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms
  • Expertise and proven application of PKPD methods and concepts in support of drug discovery and development; systems modelling experience would be advantageous
  • Demonstrated experience in developing and executing effective nonclinical PKPD strategies from early discovery through to clinic
  • Innovative, self-motivated, team-oriented scientist with good written and verbal communication skills, able to handle several projects at any given time, to work successfully in teams and to communicate clearly to a variety of audiences.
  • Demonstrated leadership skills in a matrix environment, capable of working effectively in teams and influencing relevant stakeholders
  • Experience working within a matrix environment with a wide range of internal stakeholders including Non-Clinical Safety, Bioanalysis, Clinical Pharmacology and Translational Medicine.
  • Record of publications and other external scientific contributions relevant to PKPD
  • Experience in using modelling and simulation packages such as Phoenix, Berkeley Madonna, Monolix, R, etc

 

We can offer you a competitive salary and attractive benefits package.

Closing date for applications 1st August 2019


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