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Group Leader - Molecular Pharmacology


Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  66414

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?



Role overview

We are currently seeking a highly motivated Biochemist to lead a team of molecular pharmacologists developing and performing both protein-based and cell-based assays.  The successful candidate should have practical experience of devising and implementing biochemical screens and ideally possess the mathematical/kinetic background knowledge to troubleshoot experiments, devise mode of action studies and tutor this experienced group.


Managing the Molecular Pharmacology team, you will be a leader of a small team in the Target based drug screening (TBDS) group working seamlessly with the SPR and Biophysics team.  The TBDS team support target-based screening and MOA studies for small molecule (NCE) and biologic (NBE) projects throughout the company.  The team sits within the New Modalities group within Discovery Sciences, but works very closely with the In vitro pharmacology group based in the Therapeutic Area (TA) division. The new Leader and their team will be intimately involved in early stage / pre-clinical projects which can operate across multiple sites including UK, Belgium and US and across all our current clinical areas of focus: inflammation immunology and neurology.


This role will be located in Slough, UK.


Primary responsibilities

Working within the TBDS, you will lead a team that is responsible for primary assays and mechanism of action studies to support our NCE and NBE projects.  This will involve new assay development and the implementation of cutting-edge ideas to support therapeutic project initiation and progression. 


The main aspect of the role will be to direct a group of biochemists in performing fluorescent-based protein assays (e.g. FRET and FP) and cell-based reporter gene assays as well as platforms such as NanoBret.  Often it will involve establishing new assays for traditionally difficult targets such as those involved in protein: protein interaction.  You will also be expected to support projects both early and late stage with mode of action studies. 


The ability to ‘think outside the box’ to solve complex problems is also an asset to the group based in the wider discovery team, as therapeutic modalities may not be limited to traditional small molecules and antibodies. You will also be IT literate and an experienced user of instrument operating and data processing software, including curve fitting and statistical software. In addition, you will be flexible, with the ability to appreciate how new technologies can aid the drug discovery process.  You will be an excellent communicator with the requisite skills to develop the team members; have a drive to deliver and thrive in an exciting research environment.


Essential requirements

The position would suit a PhD (or equivalent) with demonstrable practical experience in assay development and mechanism of action studies. The ability to react to and implement new ideas and technology is essential.  In addition to having excellent technical and scientific skills, you must have the ability to manage and develop a team of experienced scientists; be able to invent and implement innovative ideas; have good communication skills; and be able to operate across teams and disciplines throughout the company.


About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

Job Segment: Manager, Pharmacology, Neurology, Biochemistry, Immunology, Management, Healthcare, Science

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