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Physician TM


Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  65823

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives. 


Role overview

As Physician, Translational Medicine Immuno-bone, the role holder is accountable for providing clinical drug development and medical expertise to Immuno-bone projects to successfully deliver novel candidates through to proof of concept (PoC).  This support will include leadership and input to all clinical aspects of early drug development, ranging from input to target selection through to PoC decision point. They will principally achieve this by working as a key member of the TA project team and subsequently the Clinical Sub-Teams (CST) which they may lead. They will be recognised as an expert in all clinical aspects of the learn phase of drug development applied to the Immuno-bone disease area. 


The role will include development and maintenance of a network of key opinion leaders (KOLs) with critical scientific and clinical expertise relevant to the advance of Immunology candidates.  This will include working with external experts to establish Translational Medicine study methodologies that can be applied to Immuno-bone clinical development programs. 


The role will be located in Slough, UK. 


Primary responsibilities

Strategy and Leadership: Provide clinical leadership at all stages of Immuno-bone project progression from target selection through to PoC. Following candidate selection and through early clinical development this may will be via the role of Clinical Subteam leadership or study physician.

Work in partnership with other key lines (eg Research, SSI, Development Sciences/QCP, GCSO, Regulatory) to ensure all clinical aspects of the development plan are of high quality. This includes devising a feasible, efficient and innovative clinical plan, with clear decision points/criteria to inform project progression to PoC.

Provide major input to the Translational Medicine strategy for a project or range of projects within the Immuno-bone portfolio to PoC.

Ensure alignment of early clinical strategy and decision criteria with objective criteria within the TPVP, enabling seamless transition post-PoC to late phase development.  

As required, provide TM input to UCB Immuno-bone strategy, including alignment with TA and i/bPVU/Practices.

Provide clinical input to licensing opportunities.

Provide clinical input to project or therapeutic area-related scientific advisory boards.

May represent TM at internal strategic (ITAS) or governance bodies (DPM, EDB, PSB).

Establish and leverage KOL network to establish high value research collaborations and inform TM Immuno-bone and TA strategy. 

Operational delivery:  Act as study physician for project clinical studies (phase I-IIa, as well as relevant Translational Medicine studies). This will include design and protocol authoring, medical input to study operational set-up procedures and regulatory interactions, medical oversight/monitoring of studies, results interpretation and presentation.

Ensure clinical/medical feasibility of study protocols. 


Essential requirements

Registered medical doctor (preferably with MD or PhD post-graduate qualification, or equivalent) with extensive experience in clinical Immunology, Rheumatology or other relevant specialties eg Allergy, Dermatology.

Experience in early drug development either as PI/sub-PI in external clinical trials as a practicing clinician, or gained via industry roles.

Proven track record of successful leadership of and contribution to clinical/scientific projects.

Strong academic and clinical record in relevant immunology- or bone -related specialty.  

Demonstrable knowledge of and strong aptitude for early clinical drug development.

Demonstrate good understanding of research principles and technologies underpinning pre-clinical drug development in immunology and / or immuno-oncology area.

Inquisitive mindset and good problem solver.

Strong drive to initiate and apply innovative approaches to early drug development.

Strong leadership skills, delivering projects of high quality, to time and on budget.

Communicates effectively with internal and external stakeholders including project team members, senior management, key opinion leaders and regulatory agencies.

Inclusive, enthusiastic and collegiate approach enabling high quality performance in a matrix environment. Able to manage uncertainty and organisational change.

Exemplifies UCB shared competencies consistent with our Patient Value Strategy.

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