Principal Scientist - Fibrotic Remodelling

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Date: Jan 8, 2019

Location: Slough, Berkshire, GB

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe diseases. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives. 

 

Role Overview

To provide in vivo pharmacology expertise in models of fibrotic diseases across one or multiple organs.

 

Reporting to the Director of Pre-clinical fibrosis, this appointment will be responsible for running studies in various pharmacology models of fibrotic diseases.  The role will necessitate acting as the pharmacology lead on multiple projects where in vivo evaluation of a novel therapeutic is warranted.  They will have to work within multidisciplinary protect teams to coordinate studies in a time critical manner.  The ability to evaluate fibrotic tissues at the histology, protein and molecular level and communicate this in a concise but knowledgeable manner will be essential to cohesive team working.

 

The role will require maintenance of a home office personal licence and he/she will ultimately be expected to hold relevant home office project licences.  There will be an absolute requirement to develop new models and introduce various technologies to test therapeutic pathways such as siRNA delivery and hydrodynamic transfection.  He/She will need to align with key internal stakeholders across UCB’s research sites to define specific studies, approaches and priorities, while working closely with external collaborators. 

 

Primary Responsibilities 

In Vivo Fibrosis Pharmacology

  • Acting as the pharmacology lead on multiple project teams
  • Running renal, pulmonary, hepatic, dermal and gastric models of fibrotic modelling which will be treated with novel therapeutic small molecules, antibodies or nucleic acids
  • Coordinating in vivo studies across the fibrosis portfolio to ensure high efficiency and timely delivery of studies
  • Performing in depth analysis of tissues to assess degree of fibrotic remodelling and thus the effect of a therapeutic intervention
  • Presentencing study data to project teams and higher management
  • Mentor and train junior pharmacologists

 

Other activities

  • Support of in vitro fibrosis models
  • Technology development
  • Home Office project license applications

 

Technical capabilities

  • Strong scientific and technical competencies in the area of fibrotic remodelling in either lung, liver, skin or gut.  Ideally, but not essential is expertise across 2 or more organs. A strong publication record in fibrotic diseases is essential
  • Direct experience and track record of successfully running in vivo pharmacology studies in lung, liver, skin or gut with measurement of organ function. 
  • Previously held a home office personal licence
  • Strong tissue histology knowledge with experience of quantification of disease by high content image analysis
  • Strong inter-personal and communication skills with the ability to develop long lasting productive relationships
  • Attention to detail is essential with the ability to work closely with finance, legal and IPD 

     

Essential Experience

The candidate should have a PhD (or equivalent experience) in a life science discipline with a strong background in fibrotic remodelling and have current in vivo skills holding a home office personal licence.  They should have practical experience of both surgical and chemically induced models of fibrotic disease.  The team seeks to strengthen expertise in liver, lung, skin and gut fibrosis so would be preferred, although not essential areas of expertise.

The ideal candidate would have some years of expertise in an industrial setting (biotechnology or pharma) or have at least 5 years post-doctoral experience in an academic setting.  An experienced degree level technician with extensive experience in a relevant fibrotic disease would also be considered.  

 

We can offer you informal and open working environment that does not lock scientists into structure and hierarchy.  Freedom to take space to pursue your own ideas and make a difference.  Opportunities and expectations to develop global visibility and an international reputation as a scientist in your field.


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