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Let's push the boundaries together and make the most of your talents!

Principal Scientist - Histology

Location: 

Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  70270

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

 

The Immunology Therapy Area (ITA) group is positioned within the function of Early Solutions, which as a department investigates the target biology, mechanism of action, disease indication selection and biomarker development, significantly impacting on the progression of our portfolio of early stage development and pre-clinical therapy programmes.

 

We are seeking an enthusiastic individual to join our expanding Tissue Analytics and Imaging team in ITA at UCB.  We are looking for an individual with experience, and well-developed skills in developing, optimising and troubleshooting complex immunohistochemical assays (both chromogenic and fluorescent), including multi-plex IHC assay development, in-situ hybridisation (RNAscope), and ideally experience in IHC/ISH multiplexing.

 

The facility is well equipped with the very latest equipment for automated immunohistochemistry (Leica Bond and Ventana Discovery Ultra), whole-slide scanning in fluorescence and brightfield (ZEISS Axio Scan.Z1 and Olympus VS120) as well as image analysis (VisioPharm).

 

The role is based in Slough, UK.

 

Role overview

We are seeking a high calibre, lab-based Immunohistochemistry scientist, highly skilled in multiplex assay development and image analysis to join the ITA team. The required candidate should have a strong scientific background, good written and verbal communication skills and be highly self-motivated with a proven ability to multi-task effectively and adapt to meet the demands of a fast-paced environment.

 

This exciting role is available at our site in Slough, UK, where your expertise will be key in progression of our portfolio of pre-clinical and early-stage development programmes as well as our biomarker development projects. The breadth of work will cover a range of histological, immunohistochemical and immunofluorescent techniques, specially the development of multiplex staining protocols, as well as taking a lead role in working with CROs.

 

Successful candidates will be working in a dynamic, multi-disciplinary environment, able to apply their skills to influence projects across a spectrum of immune, bone and similar disease areas.

 

Primary responsibilities

  • Maintain operational functionality of equipment and technologies, including hardware, software, procedures and the laboratory spaces in which the equipment are housed.
  • Be a key source of information relating to the field of expertise, leasing internally and externally.
  • Troubleshoot issues and react timely to ensure continuous operation and uninterrupted assay workflows.
  • Maintain grounded relationships with vendors who provide parts, software upgrades, training, updates and new release of information.
  • Working with project teams, develop and design assays that reflect the biology of our targets.
  • Ability to analyse, interrogate data and troubleshoot technical issues.
  • Present experimental data at cross-functional meetings and external conferences.
  • Maintain compliant procedures by completing training modules and maintaining experimental records.
  • Display awareness of published literature and externally available platforms and technologies.
  • Depending upon experience, contribute to the development and incorporation of new technologies and/or techniques and mentoring/training of other scientists.
  • You are required to comply with HTA regulations, ensuring that relevant training is up-to-date and that you have read and understood the HTA Policies and Procedures Manual.
  • Maintain Health & Safety awareness to ensure safe working practices for our staff and contractors.

 

Skills and experience

  • Candidates should have a BSc/MSc in a biological discipline with substantial post-graduate experience. Post-doctoral experience will be highly valued.
  • Practical experience in general histology methods, immunohistochemistry and In-situ hybridization, with both chromogenic and ideally fluorescence methodology. Prior experience with autostainers an advantage.
  • Experienced in development of staining protocols for novel antibodies/antigens including multi-plex approaches for fluorescent or chromogenic based techniques.
  • Practical experience with in situ hybridisation techniques such as RNAscope.
  • Demonstrated experience in whole-slide scanning, analysis and digital Image analysis would be highly advantageous.
  • Experience in Lab supervisory and mentoring roles
  • Experience in tissue processing including fixation, embedding, sectioning of FFPE and frozen tissues or other range of histological techniques including special staining procedures such as Masson’s Trichrome, Picrosirius Red, etc will be taken into account.
  • Excellent communication skills, team working and the flexibility to work in new and challenging areas are required.
  • Key attributes include a pro-active approach, strong team ethic and the ability to build relationships and work effectively across functions.
  • Maintain awareness of developments in the field, be pro-active in introducing new techniques and capabilities

 

Preferred

  • Experience of working in a pharmaceutical drug discovery and development environment.
  • Experience of working with human tissue under the directives of the Human Tissue Act (HTA).
  • Experience of working with electronic lab notebooks
  • Experienced in Imaging Mass Cytometry or multiplexed ion beam imaging will also be considered for our developing aspirations

 

We can offer you a structured career development programme designed to enhance your technical and scientific skills and equip you to further your career in industry and drug discovery.  There will be early opportunities to make an impact by working in small scale teams where your contribution will be clearly visible and recognised and most importantly, will help bring solutions to transform the lives of people with severe diseases.

 

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 


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