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Senior Scientist/Principal Scientist - Omics

Location: 

Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  65050

Posting date: 22nd October 2019

Closing date: 29th November 2019

 

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

 

Role overview

Translational Biomarkers and Bioanalysis is looking for a high caliber, experienced and self-motivated scientist to work within our growing transcriptomics / omics area within TBB to develop the development of transcriptomic, metabolomics and proteomics derived biomarkers into the clinic. The successful candidate will have a strong scientific background, good written and verbal communication skills and be able to multi-task effectively and adapt to meet the demands of a fast-paced matrix-team environment.

 

The role is based in Slough, UK.

 

Primary responsibilities

  • You will employ your proven expertise to development and deliver assays in the transcriptomics area with responsibility for translating transcriptomics biomarkers into the clinic.
  • Play a key part in delivering the strategy of the TBB team to ensure and input into the omics strategy.
  • Develop complex proteomic-based quantitative pharmacodynamic biomarker assays for measuring analytes in a range of non-clinical and clinical sample types.
  • Work with key stakeholders to ensure prioritization and optimal deployment of technologies.
  • Work with CROs to transfer and deliver key assays to clinical deadlines.
  • Work with scientists in discovery and the therapeutic areas as well the clinical scientists to develop and implement novel biomarkers.
  • Work within the Bioanalytical area to optimize experimental design, troubleshooting, sample analysis, data interpretation and report generation.
  • You will have in-depth knowledge to provide scientific and technical input to Project teams, Biomarker teams and Development Sciences teams.
  • Liaise with statistics and bioinformaticians to ensure optimum design of experiments.
  • Ensure compliance with all health and safety regulations.
  • Develop and grow links with key academic collaborators.
  • Work within collaborations with external partners, academic institutions, CROs and consultants as required.
  • Maintain an awareness of new / emerging techniques and tools relevant to the field to ensure the group remains state of the art.
  • Represent and align with the objectives of Development Sciences internally and externally in matters relevant to biomarkers and bioanalysis.

 

Essential experience

  • Candidates should have a minimum of BSc (or equivalent) and preferably a PhD (or equivalent) in a biological discipline.
  • Extensive and proven experience of working in the area of transcriptomics and potentially other omics such as metabolomics and proteomics.
  • Experience of working in a matrix to generate and disseminate key data.
  • An ability to prioritise projects effectively and delivery to key deadlines.
  • Experience of commissioning and working with specialist CROs to deliver data to defined timescales.
  • Clear practical experience in a range of methodologies, including transcriptomics and preferably other omic technologies.
  • Proven track record of developing novel solutions in a discovery and preferably a clinical setting.
  • Demonstrated ability to generate and analyse large omics- derived data sets in collaboration with statisticians and bioinformaticians.
  • Demonstrated ability to work effectively in a dynamic laboratory environment to project timelines.
  • An ability to work in a matrix and communicate clearly to colleagues and project scientists, able to discuss ideas, provide constructive challenge and useful feedback.
  • A keen understanding of the impact of biological and assay variability on experimental design and delivery.
  • Adaptable to changing project and organizational priorities and consistently aligned with departmental needs.

 
Preferred experience

  • Previous experience of working in a pharmaceutical drug discovery and development environment.
  • An understanding of genetics would be a distinct advantage
  • Good working knowledge of neuroscience, immunology and / or cancer biology
  • Experience with the appropriate biomarker assay validation towards supporting clinical assessments and knowledge of the latest regulatory standards
  • Experience working with a wide range of internal stakeholders including Therapeutic Area, Non-Clinical Safety, DMPK, Translational Medicine, Clinical Pharmacologists, Pathologists, Biostatisticians, Clinical operations and Quality Assurance colleagues.
  • Experience of working as a departmental representative in a project matrix
  • The analysis of pharmacodynamic endpoints
  • Clear grasp of context of use (linking assay requirements to the usage of the data generated) of biological data
  • Knowledge of the latest regulatory standards and industry best practices

 

We can offer you plenty of scope to influence the pipeline and make a difference to patients, with the potential to influence the strategy and drive the science.  UCB is a great place to get a breadth of experience of the drug pipeline, from research through to the clinic within a highly collaborative environment.  To learn, contribute and gain visibility in a scientific and cross functional setting.  A competitive salary and benefits package.


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