Loading...
Share this Job

 

Let's push the boundaries together and make the most of your talents!

Principal/Senior Scientist - Biomarker Immunoassay Development

Location: 

Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  65053

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

 

The Translational Biomarkers and Bioanalysis group is positioned within Development Sciences, which as a division provides strategy and support in integrated pharmacokinetics/pharmacodynamics and DMPK, bioanalysis, immunogenicity, safety, pathology, and regulatory activities throughout the lifespan of projects, from target identification through to clinical studies. The Translational Biomarkers and Bioanalysis department operate and collaborates closely with colleagues in Development Sciences and across the organization to support bioanalysis and biomarker activities.

 

Role overview

The Biomarker Immunoassay Group within Translational Biomarkers and Bioanalysis is looking for high caliber, self-motivated candidates with a strong scientific background and an interest in a dual lab-based as well as Project Team-facing role, with good written and verbal communication skills and who can multi-task effectively and adapt to meet the demands of a fast-paced, collegiate, results-driven matrix-team environment that provides multiple opportunities to progress based on  talent, ability and initiative.

 

The role is based Slough, UK.

 

 Role overview

  • You will employ your expertise for the development of complex biomarker assays for measuring analytes in biofluids and tissue samples exploring diverse approaches to ensure delivery of high-quality fit-for-purpose assays
  • Using in-house developed or commercially available immunoassays to measure the levels of biomarkers and biologic drug candidates
  • Assessment of novel biomarkers to ensure right dose, right molecule and right patient population within future clinical trials
  • Where appropriate, characterize antibodies, conduct reagent evaluation and perform reagent qualification assays
  • Provide in-depth knowledge of assay development and troubleshoot technical challenges across multiple platforms
  • Provide the appropriate levels of assay quality to ensure fit for purpose use.
  • Work within the Bioanalytical area to optimize experimental design, troubleshooting, sample analysis, data interpretation and report generation
  • You will have in-depth knowledge of bioanalytical tools to provide scientific and technical input to Project teams, Biomarker teams and Development Sciences teams
  • You will act as subject matter expert for biomarker immunoassays transferred to Clinical Research Organizations
  • Liaise with statisticians and bioinformaticians to ensure optimum design of experiments
  • Ensure compliance with all health and safety, HTA, other regulations
  • Work within collaborations with external partners, academic institutions and consultants as required
  • Maintain an awareness of new / emerging techniques and tools relevant to the field.
  • Represent and align with the objectives of Development Sciences internally and externally in matters relevant to biomarkers and bioanalysis

 

Essential experience

  • Extensive hands-on direct recent expertise with development of ligand binding assays/immunoassays from starting principles
  • Proven experience in immunoassays, including ELISA, MSD, high sensitivity platforms such as Singulex, Simoa/Quanterix, other
  • Proven track record of developing novel fit for purpose immunoassay biomarker assays from first principles for pre-clinical and clinical assessments.
  • Experience with appropriate biomarker assay validation, towards supporting clinical assessments and demonstrable knowledge of the latest regulatory standards, industry best practices, attendance at relevant biomarker conferences
  • Clear grasp of context of use (linking assay requirements to the usage of the data generated)
  • A keen understanding of the impact of biological and assay variability for fit for purpose biomarker assay development and data interpretation and proven expertise in delivery
  • Proven experience of factors for consideration for selection of appropriate endogenous controls
  • Proven experience of biomarker assay development with diverse types of tool reagents
  • Demonstrated ability to multi-task effectively in a dynamic laboratory environment to project timelines with minimal supervision
  • An ability to work in a matrix and communicate clearly to colleagues and project scientists, able to discuss ideas, provide constructive challenge and useful feedback.
  • Adaptable to changing project and organizational priorities and consistently aligned with departmental needs
  • The applicant should have a BSc in a biological discipline
     

Preferred experience

  • Effective ability to progress Biomarker assessments from Research through into Clinical Development
  • Previous experience of working in a pharmaceutical drug discovery and assay development environment.
  • Experience working with a wide range of internal stakeholders including Therapeutic Area, Non-Clinical Safety, DMPK, Translational Medicine, Clinical Pharmacologists, Clinical operations and Quality Assurance colleagues.
  • The analysis of pharmacokinetic and pharmacodynamic endpoints
  • Established track record of working with Clinical Research Organizations in support of clinical immunoassay biomarker assessments
  • Experience of working with electronic lab notebooks
  • Knowledge of statistical tools for the analysis of assays

 

We can offer you plenty of scope to influence the pipeline and make a difference to patients, with the potential to influence the strategy and drive science.  UCB is a great place to get a breadth of experience of the drug pipeline, from research through to the clinic within a highly collborative environment.  To learn, contribute and gain visibility in a scientific and cross functional setting.


Job Segment: Biotech, Scientific, Pathology, Scientist, Law, Engineering, Science, Healthcare, Legal