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Scientist: Upstream Process Science

Location: 

Slough, Berkshire, United Kingdom

Job Function:  Process & Technology Development
Job ID:  64411

Scientist: Upstream Process Sciences
UCB – Inspired by patients. Driven by science.
Help us transform patients’ lives.

About UCB

At UCB, we put our heart, soul and skills into making a difference for people living with severe diseases. We look to transform patients’ lives by pushing the boundaries of what is possible. With us, our talent makes the most of who they are, unlocking innovation and setting new standards for patients.

 

Everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” And to find the answers, we connect globally with patients and their families living with the physical and social burdens of severe disease. These connections give us new perspectives, drive our innovation, and offer a hope for a new generation of therapies that will help to transform lives.

 

To strengthen our Technical and Supply Operations Group, we are looking to fill the position of: Scientist: Upstream Process Sciences.

 

 

What We Offer
An opportunity to:

  • Work in a team environment, collaborating with various process scientists (upstream and downstream) and analytical scientists.
  • Utilize your knowledge in biochemical engineering, chemical engineering, statistics, molecular biology, analytical methods and cellular metabolism to aid in process development and optimization of upstream processes producing protein therapeutics for early and late stage projects.
  • Contribute to scientific development and technology development projects requiring innovative research, to improve USP and primary recovery processes and understanding.

 

About the Role
You will be responsible for:

  • Performing upstream process development experiments for the development of new manufacturing processes and the improvement of existing processes at lab and pilot scale; including all upstream and primary recovery activities as well as associated purification and analytical methods.
  • Trending and analysing laboratory data. Presenting results to your line manager, USP team and at internal meetings.
  • Determining process limits as part of process understanding, characterisation and validation studies.
  • Providing traceable records of lab work, experimental design and report writing.
  • Providing technical expertise in upstream processing for internal customers.
  • Providing upstream processing support to internal manufacturing, CMO and technology transfer teams as appropriate.
  • Managing placement students and/or associate scientists as appropriate.  
  • Supporting team compliance with all quality management systems, including reviewing, writing and updating internal procedures and documents (e.g. Lab procedures, SOPs, templates).

 

About You
You should have:

  • Previous extensive experience in mammalian cell culture.
  • Experience working with bioreactors and harvest processes across scales (cell culture processes).
  • Strong Lab skills with proven troubleshooting capability (the role will be lab based).
  • Excellent scientific method – experimental design, analysis and interpretation of results.
  • Knowledge/experience in tech transfer/scaling up of processes.
  • Experience in a process development environment.
  • Sound understanding of physiology, metabolism and molecular biology of microbial and/or mammalian cells.

 

Desired skills include:

  • Experience with high throughput technologies, automation, miniaturisation (Ambr250, Tecan, Hamilton systems).
  • Programming background/experience (e.g. Visual Basic, Python, Matlab).
  • Ability to learn and use appropriate data management concepts and tools (e.g. electronic lab notebooks, SDC, Discoverant).
  • A good understanding of statistical methods applied to data analysis and comparability.

 

UCB – The Facts

With more than 7500 employees in approximately 40 countries, we are a global biopharmaceutical company headquartered in Brussels, Belgium which invests more than 25% of revenue in cutting-edge scientific research to meet unmet patient needs. A few other reasons that make UCB an amazing place to work:

  • Promising pipeline that includes several novel molecules and no major patent expiration in the next decade;
  • About 25% of 2016 revenue reinvested into Research & Development
  • 2016 Key Financials: €4.2 billion global revenue Specialties: Neurology, Immunology


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