Senior Cell Culture Scientist - Cell Line Development Group

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Date: May 5, 2019

Location: Slough, Berkshire, GB

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

 

Role overview

We are currently seeking a highly skilled Cell Culture / Expression Scientist, with experience in the generation and optimisation of stable mammalian cell lines for the expression of proteins. The successful candidate will be employed in the Cell Line Development sub-team which is part of the Antibody Biology Group.  Within the Antibody Biology Group, this team focuses on the generation of stable mammalian cell lines and the development of manufacturing processes.  

 

This position will be located in Slough, UK.

 

Primary responsibilities

  • Lab based scientist with science leadership skills taking a lead role in the planning, design and delivery of stable mammalian cell lines for the expression of proteins
  • To optimise cell culture processes, identify bottlenecks and implement solutions.
  • To Identify and implement novel technologies
  • To analyse and understand data to inform on selection of best stable cell line clones for manufacture
  • Communication both within the Cell Line Development Group and across multiple disciplines (Project Teams, Antibody Discovery, Intellectual Property and Clinical Production Teams) ensuring that information on work progress is relayed in a clear manner, highlighting any technical issues/opportunities and providing potential solutions
  • Understanding the protein needs of early stage projects and therapeutic area scientists along with coordination of delivery with project teams.

 

Essential requirements

We are looking for candidates who can demonstrate working knowledge of most of, and expertise in some of the following skill sets;

  • Understanding of the regulatory requirements for the production of  therapeutic antibodies and therapeutic non-antibody proteins.
  • Familiar with lab and manufacturing scale mammalian cell expression systems with a good working understanding of cell culture laboratory equipment including vicells, FACS, Octet, AMBR systems and ideally laboratory automation.
  • Demonstrable understanding and ability to interpret molecular biology, protein purification data and analytics including plasmid production / DNA sequencing, expression, affinity chromatography, ion exchange, SEC, ELISA, SDS PAGE.
  • General knowledge of lab software systems including Office, eLabBooks, along with searching for literature and patents.

    Excellent verbal, written and presentation communication skills which can be used both within and outside of UCB.

    Publication of papers, patent applications and conference presentations.

    Ideally with national / international connections within the scientific community.

    Understanding of the pre-clinical drug discovery and clinical drug development phases.


Job Segment: Scientific, Medical Lab, Biology, Cell Biology, Developer, Engineering, Healthcare, Science, Technology

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