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Senior Drug Discovery Scientist - Gene Silencing and Editing


Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  65375

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.


Role overview

Working in the New Modalities and Therapeutics group within Discovery Sciences in Slough UK, you will be part of an innovative multi-disciplinary team, within the Discovery Biology Division.


Primary responsibilities

The ideal candidate will take a role in expanding our capabilities in antisense, siRNA, CRISPR and mRNA, primarily as tools to validate new drug targets.


Through your role, you will enhance our ability to rapidly assess and progress drug targets and modalities into UCB’s drug portfolio. This will require excellent practical skills and an understanding of the nature of drug discovery for small and large molecule drugs. In particular, expertise in the therapeutic use of nucleotide therapies (for example antisense oligonucleotides or siRNA) from validation through to the development of genetic medicines will be an asset for this role. Interaction with different teams in Discovery Sciences is vital as is the connection with research teams throughout the organisation.


The successful candidate will have an impact on the adoption of new therapeutic concepts that will benefit the lives of patients and be at the cutting-edge of new medicines.


Essential requirements

Post-doctoral experience or a newly qualified PhD (or equivalent)

Design and research use of antisense, siRNA, CRISPR or mRNA.

Extensive drug target validation experience using externally sourced reagents and technologies – for example antisense, siRNA, CRISPR or mRNA.

Quantification of gene expression changes using qPCR and protein detection methods.

The ability to design and test validation technologies in either biochemical or cellular assays.

Excellent communication skills and a track record of working effectively in teams.

Desirable requirements

Experience in novel drug discovery.

A history of design and manufacture of antisense, siRNA, CRISPR or mRNA drugs.

Strong awareness and ability to advise on the external RNAi and mRNA environment especially intellectual property.

Experience with additional biochemical assay techniques – for example SPR


We can offer you an excellent opportunity to join an exciting company.  In return UCB is offering a competitive salary package, continuous professional and personal development, training and career progression.

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