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Senior Scientist - Plasmid process development


Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  67162


Senior Scientist – Microbial Upstream Process Development for Plasmid Production


To strengthen our Upstream Process Sciences team, based in our UK Research and Development Site in Slough, we are looking for a talented individual to fill the position of: Senior Scientist – Microbial Upstream Process Development for Plasmid Production.

As a Senior Scientist you will be supporting our gene therapy programs by helping to build UCB’s internal plasmid process development knowledge whilst also supporting the microbial process development for other therapeutic programs. The ideal candidate will be a talented Biochemical / process engineer with experience of microbial process development for production scale manufacturing of plasmid DNA.

You like to work in an environment where you can:

  • Apply your existing knowledge to develop new processes and solve new challenges.
  • Act as a subject matter expert, making a significant contribution to UCB’s knowledge and understanding of plasmid process development.
  • Work with an international mindset – collaborating with colleagues across departments and geographical locations.


You will contribute by:

  • Developing upstream processes for plasmid DNA production as input to Gene Therapy products, working with equipment at shake flask, ambr250, 5L and 200L scales.
  • Identifying scale-up challenges and developing robust processes for tech transfer to manufacturing scale.
  • Developing and optimising efficient microbial fermentation, lysis and primary recovery steps.
  • Evaluating equipment improvements for automation of process operations and sampling.
  • Collaborating with the discovery, AAV development, downstream and analytics teams.
  • Functioning independently and cross functionally across various UCB teams (including cell line development, Vector Core, quality, analytics etc).
  • Ability to manage priorities and engage/communicate in a multidisciplinary environment.


Interested? For this position you’ll need the following education, experience and skills:

  • Preferably a Ph.D. in Biochemical Engineering, cellular biology, biochemistry, or equivalent.  
  • Direct industry experience with bioreactor and primary recovery operations for the development of plasmid DNA or biologics products.
  • Knowledge of molecular biology and analytical methods.  
  • Previous use of DOE methods in development are strongly preferred.
  • Knowledge of, and experience in analytical methods relevant to plasmid DNA production is preferred.
  • Strong communication skills and previous experience working in cross-functional teams preferred.


Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.


If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.


Apply now »