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Senior Scientist/Principal Scientist - Proteomics


Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  65051

Posting date: 22nd October 2019

Closing date: 19th November 2019


At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.


The Translational Biomarkers and Bioanalysis (TBB) Department is positioned within the function of Development Sciences, a division which provides strategy and support to transition novel pharmacological assets from research into the clinic. TBB operate and collaborate closely across the organization to support bioanalysis and biomarker activities.


Role overview

Translational Biomarkers and Bioanalysis is looking for a high caliber, experienced and self-motivated scientist to work within our growing proteomics/genomics area within TBB. The successful candidate will have a strong scientific background, good written and verbal communication skills and be able to multi-task effectively and adapt to meet the demands of a fast-paced matrix-team environment.


The role is based in Slough, UK.


Primary responsibilities

  • You will employ your proven expertise to development and deliver assays in the proteomics area.
  • Play a key part in delivering the strategy of the proteomic team to ensure the continuous evolution of the science and technology and deliver key data to project teams.
  • Develop complex proteomic-based quantitative pharmacodynamic biomarker assays for measuring analytes in a range of non-clinical and clinical sample types.
  • Work key stakeholders to ensure prioritization and optimal deployment of technologies.
  • Using untargeted and targeted proteomics to discover, develop and implement novel biomarkers.
  • Work within the Bioanalytical area to optimize experimental design, troubleshooting, sample analysis, data interpretation and report generation.
  • You will have in-depth knowledge to provide scientific and technical input to Project teams, Biomarker teams and Development Sciences teams.
  • Liaise with statistics and bioinformaticians to ensure optimum design of experiments.
  • Ensure compliance with all health and safety regulations.
  • Develop and grow links with key academic collaborators.
  • Work within collaborations with external partners, academic institutions, CROs and consultants as required.
  • Maintain an awareness of new / emerging techniques and tools relevant to the field to ensure the group remains state of the art.
  • Represent and align with the objectives of Development Sciences internally and externally in matters relevant to biomarkers and bioanalysis.
  • Provide subject matter expertise across UCB portfolio (NS, IB, Onc including new modalities such as Gene and cell based therapies.


Essential experience

  • Candidates should have a BSc (or equivalent) and preferably a PhD (or equivalent) in a biological discipline.
  • Extensive and proven experience of working in the area of Proteomics.
  • Experience of working in a matrix to generate and disseminate key data.
  • Good working knowledge of neuroscience, immunology and / or cancer biology.
  • An ability to prioritise projects effectively and delivery to key deadlines.
  • Clear practical experience in a range of methodologies, including targeted and untargeted proteomics.
  • Proven track record of developing novel solutions in a discovery and preferably a clinical setting.
  • Demonstrated ability to generate and analyse large proteomics data sets.
  • Demonstrated ability to work effectively in a dynamic laboratory environment to project timelines.
  • An ability to work in a matrix and communicate clearly to colleagues and project scientists, able to discuss ideas, provide constructive challenge and useful feedback.
  • A keen understanding of the impact of biological and assay variability on experimental design and delivery.
  • Adaptable to changing project and organizational priorities and consistently aligned with departmental needs.

Preferred experience

  • Previous experience of working in a pharmaceutical drug discovery and development environment.
  • Experience with the appropriate biomarker assay validation towards supporting clinical assessments and knowledge of the latest regulatory standards.
  • Experience working with a wide range of internal stakeholders including Therapeutic Area, Non-Clinical Safety, DMPK, Translational Medicine, Clinical Pharmacologists, Pathologists, Biostatisticians, Clinical operations and Quality Assurance colleagues.
  • The analysis of pharmacodynamic endpoints.
  • Experience of working as a departmental representative in a project matrix.
  • Clear grasp of context of use (linking assay requirements to the usage of the data generated) of biological data.
  • Knowledge of the latest regulatory standards and industry best practices.


We can offer you plenty of scope to influence the pipeline and make a difference to patients, with the potential to influence the strategy and drive the science.  UCB is a great place to get a breadth of experience of the drug pipeline, from research through to the clinic within a highly collaborative environment.  To learn, contribute and gain visibility in a scientific and cross functional setting.  A competitive salary and benefits package.

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