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Let's push the boundaries together and make the most of your talents!

Principal Scientist - Cheminformatician


Boston, Massachusetts, United States

Job Function:  Research & Early Development
Job ID:  63958

Help us transform patients' lives.

At UCB, we put our heart, soul and skills into making a difference for people living with severe diseases.  Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in this pioneering adventure? 


To strengthen our Early Research and Development Team, based in our Boston office in Bedford, MA, we are looking for a talented individual to fill the position of: Principal Scientist.


You like to work in an environment where you can:


Role Overview

The successful applicant will demonstrate excellent scientific judgement and be a recognised cheminformatics expert in the field of DNA-encoded libraries with a proven track record and in-depth knowledge of the area. She/He will be instrumental in establishing a DNA-encoded library platform with the clear objectives of designing high-quality libraries, establishing data analysis platform, and performing hands-on analysis of screening data and hit triage. The role will require extensive collaboration with scientists across our research sites and with external collaborators and CROs.


Primary roles and responsibilities

  • A key contributor to UCB’s DNA-encoded library platform strategy and its implementation.
  • Lead the computational efforts to design DNA-encoded libraries by working with internal and external collaborators.
  • Acquire, develop and/or implement computational tools and workflows, through independent research and internal/external collaborations, for data analysis and hit triage.
  • Lead screening data analysis and hit triage in close collaboration with other UCB colleagues.
  • Contribute to hit validation and hit to lead activities.
  • Collaborate with external groups for the development of novel algorithms to enhance our computational capabilities for DNA-encoded libraries.
  • Serve as a scientific leader and cheminformatics expert in DNA-encoded libraries and provide recommendations regarding emerging external capabilities.
  • Ensure optimal interaction/communication and provide updates on project status to Chemistry leadership


Candidate requirements and qualifications

  • A PhD in cheminformatics, computational chemistry or a related field is required.
  • In depth knowledge and 5 years’ hands on experience in all computational aspects of the DNA-Encoded Library platform, including library design, data analysis, hit triage, is required.
  • Experience in programming languages such as C++ and/or Python is required.
  • Technical expertise in developing cheminformatics protocols using workflow tools (e.g., PipelinePilot) and coding toolkits (e.g., RDkit, CDK and OpenEye) is highly desired.
  • Track record of successful delivery of compound library design and chemistry technology platforms, utilizing internal and external resources, is highly desired.
  • Experience of synthetic chemistry or medicinal chemistry is desired.
  • Strong track record of scientific publications and patent applications.
  • Ability to effectively communicate and interpret experimental results using advanced data visualization is desired.
  • The ideal candidate will create effective working relationships in a matrix environment. She/he will also demonstrate a high level of entrepreneurship and foster can-do and can-win attitude. Very good knowledge of verbal and written English is essential.


Interested individuals should apply online on UCB website and include the following items:

1. A cover letter outlining research interests and experience as well as career goals

2. Curriculum Vitae

3. Expected availability


About Us

At UCB, we come together every day to work, laser-focused, on a simple question: How will this create value for people living with severe diseases? By putting patients at the heart of everything we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees worldwide operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases. We are looking for people with passion and empathy who develop a real understanding of patient’s needs and can deliver thoughtful solutions to decisionmakers across the heath care ecosystem.

Curious to know more? Please visit our website www.ucb.com.


UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. We do not discriminate on the basis of race/color/religion/sex/national origin/veteran/disability/age/sexual orientation/gender identity.

Job Segment: Chemistry, Scientific, Neurology, Immunology, Scientist, Science, Engineering, Healthcare

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