Share this Job
Apply now »


Let's push the boundaries together and make the most of your talents!

Senior/Principal Scientist - DEL Informatics


Boston, Massachusetts, United States

Job Function:  Research & Early Development
Job ID:  63958

Help us transform patients' lives.

At UCB, we put our heart, soul and skills into making a difference for people living with severe diseases.  Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in this pioneering adventure? 


Senior Scientist, Principal Scientist or Senior Principal Scientist – Chemo-Informatics for DNA-encoded Libraries; Boston, MA

We are seeking an experienced scientist and chemo-informatician to join our global Computer-Aided Drug Discovery team and broader research group in UCB’s growing US-based research hub in Bedford, MA. The Bedford site is home to a diverse group of research functions and teams such as Targeted-Protein Degradation, a growing scientific computing group, Gene Therapy, Protein production & purification, Biophysics and X-ray Crystallography. 


Our Company
UCB is a fast-moving global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases affecting the immune and central nervous systems. With more than 7,700 people in approximately 40 countries, the company generated revenue of € 4.6 billion in 2018. UCB invests more than 25% of revenue in cutting-edge scientific research with the aspiration of solving unmet patient needs. We have a passionate, long-term commitment to the discovery and development of innovative medicines that transform the lives of people with severe diseases. At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.


Role Purpose

To be successful in this role you will demonstrate excellent scientific judgement and leadership and be highly skilled in cheminformatics or data analysis.  You will have demonstrable experience and a proven track record of developing custom tools and informatics infra structure is critical, as is their application in data analysis.  You will either already have extensive experience and in-depth knowledge of all computational/informatics aspects of the DNA-encoded library (DEL) platform or have the potential to acquire them in a short time. Together with other experienced DEL scientists, you will be instrumental in advancing/completing an internal UCB DNA-encoded library platform build. The clear purpose of this role includes the design of high-quality libraries, establishing the data analysis platform, and performing hands-on analysis of screening data and hit triage. The role will require extensive collaboration with scientists across our research sites and with external collaborators and CROs.


Primary roles and responsibilities

  • A key contributor to UCB’s DNA-encoded library platform strategy and its implementation.
  • Provide leadership on the computational and data analysis efforts to design DNA-encoded libraries by working with internal and external collaborators.
  • Acquire, develop and/or implement computational tools and workflows, through independent research and internal/external collaborations, for data analysis and hit triage.
  • Lead the screening data analysis and hit triage in close collaboration with other UCB colleagues.
  • Contribute to hit validation and hit to lead activities.
  • Collaborate with external groups for the development of novel algorithms to enhance our computational capabilities for DNA-encoded libraries.
  • Provide scientific leadership and cheminformatics expertise in DNA-encoded libraries and provide recommendations regarding emerging external capabilities.
  • Ensure optimal interaction/communication and provide updates on project status to our Chemistry leadership.
  • Will create effective working relationships in a matrix environment.
  • Demonstrate a high level of entrepreneurship and foster can-do and can-win attitude.
  • Very good knowledge of verbal and written English is essential.


Candidate requirements and qualifications

Basic Qualifications:

  • PhD with 4+ years or Masters with 8+ years industry experience in cheminformatics, computational chemistry, computer/data science
  • 5+ years hands-on programming and scripting skills in Python, RD Kit, C++, R and similar
  • Authored in scientific publications and patent applications


Preferred Qualifications:

  • A PhD
  • In depth knowledge and 5 years’ hands on experience in all computational aspects of the DNA-Encoded Library platform (i.e. library design, data analysis,…)
  • Talented candidates with a documented ability to self-start and quickly acquire new skill sets but still need to develop deep DEL experience will also be considered
  • Technical expertise in developing cheminformatics protocols using workflow tools (e.g., PipelinePilot) and coding toolkits (e.g., RDkit, CDK and OpenEye)
  • Track record of successful delivery of compound library design and chemistry technology platforms, utilizing internal and external resources
  • Experience of synthetic chemistry and/or medicinal chemistry
  • Ability to effectively communicate and interpret experimental results using advanced data visualization



Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.


If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.


About Us

At UCB, we come together every day to work, laser-focused, on a simple question: How will this create value for people living with severe diseases? By putting patients at the heart of everything we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees worldwide operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases. We are looking for people with passion and empathy who develop a real understanding of patient’s needs and can deliver thoughtful solutions to decisionmakers across the heath care ecosystem.

Curious to know more? Please visit our website www.ucb.com.


UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. We do not discriminate on the basis of race/color/religion/sex/national origin/veteran/disability/age/sexual orientation/gender identity.

Apply now »