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Principal Scientist - Cheminformatician


Boston, Massachusetts, United States

Job Function:  Research & Early Development
Job ID:  63958

Principal Scientist –  Cheminformatician for DNA-encoded Libraries

We are seeking a scientific leader and cheminformatician experienced in the design and application of DNA-encoded libraries to join our research group in Bedford, MA.


The Organization
UCB is a fast-moving global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases affecting the immune and central nervous systems. With more than 7,700 people in approximately 40 countries, the company generated revenue of € 4.2 billion in 2016. UCB invests more than 25% of revenue in cutting-edge scientific research with the objective of solving unmet patient needs. We have a passionate, long-term commitment to the discovery and development of innovative medicines that transform the lives of people with severe diseases. At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

Role Overview

The successful applicant will demonstrate excellent scientific judgement and be a recognised cheminformatics expert in the field of DNA-encoded libraries with a proven track record and in-depth knowledge of the area. She/He will be instrumental in establishing a DNA-encoded library platform with the clear objectives of designing high-quality libraries, establishing data analysis platform, and performing hands-on analysis of screening data and hit triage. The role will require extensive collaboration with scientists across our research sites and with external collaborators and CROs.


Primary roles and responsibilities

  • A key contributor to UCB’s DNA-encoded library platform strategy and its implementation.
  • Lead the computational efforts to design DNA-encoded libraries by working with internal and external collaborators.
  • Acquire, develop and/or implement computational tools and workflows, through independent research and internal/external collaborations, for data analysis and hit triage.
  • Lead screening data analysis and hit triage in close collaboration with other UCB colleagues.
  • Contribute to hit validation and hit to lead activities.
  • Collaborate with external groups for the development of novel algorithms to enhance our computational capabilities for DNA-encoded libraries.
  • Serve as a scientific leader and cheminformatics expert in DNA-encoded libraries and provide recommendations regarding emerging external capabilities.
  • Ensure optimal interaction/communication and provide updates on project status to Chemistry leadership


Candidate requirements and qualifications

  • A PhD in cheminformatics, computational chemistry or a related field is required.
  • In depth knowledge and 5 years’ hands on experience in all computational aspects of the DNA-Encoded Library platform, including library design, data analysis, hit triage, is required.
  • Experience in programming languages such as C++ and/or Python is required.
  • Technical expertise in developing cheminformatics protocols using workflow tools (e.g., PipelinePilot) and coding toolkits (e.g., RDkit, CDK and OpenEye) is highly desired.
  • Track record of successful delivery of compound library design and chemistry technology platforms, utilizing internal and external resources, is highly desired.
  • Experience of synthetic chemistry or medicinal chemistry is desired.
  • Strong track record of scientific publications and patent applications.
  • Ability to effectively communicate and interpret experimental results using advanced data visualization is desired.
  • The ideal candidate will create effective working relationships in a matrix environment. She/he will also demonstrate a high level of entrepreneurship and foster can-do and can-win attitude. Very good knowledge of verbal and written English is essential.


Interested individuals should apply online on UCB website and include the following items:

1. A cover letter outlining research interests and experience as well as career goals

2. Curriculum Vitae

3. Expected availability

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