Research Associate - Targeted Protein Degradation

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Date: Jan 25, 2019

Location: Boston, Massachusetts, US

Research Associate – Functional Biology - Targeted Protein Degradation  Bedford, MA
The Organization:  UCB is a fast-moving global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases affecting the immune and central nervous systems. With more than 7,700 people in approximately 40 countries, the company generated revenue of € 4.2 billion in 2016. UCB invests more than 25% of revenue in cutting-edge scientific research with the objective of solving unmet patient needs. We have a passionate, long-term commitment to the discovery and development of innovative medicines that transform the lives of people with severe diseases. At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.  
We are seeking a Research Associate lab-based scientist with responsibility for the prosecution of in vitro biochemical and cellular assays to support drug discovery in targeted protein degradation.  
Primary Responsibilities of the Position:  • Execution of functional/cellular approaches to evaluate targeted protein degradation including assessment of target and E3 ligase biology, ubiquitin proteasome pathway, complex protein dynamics and downstream function in physiologically and biochemically relevant assays.  • Lab based scientist responsible for execution of mammalian tissue culture, cellular reporter assays and flow cytometry experiments to successfully progress drug discovery projects under aggressive timelines. • Work closely with senior scientists to provide support in executing research and experiments to support projects and platform.
Education and Experience:  Essential Requirements • BS/MS in applicable field or equivalent experience gained through industry. • 1-2 years of applicable research experience, with excellent scientific track record.   • Experience with cellular biology techniques including but not limited to cellular assays, mammalian cell culture, and other biochemical/biophysical characterization. • High attention to detail and excellent organizational skills are necessary to be successful in this position. • Willingness to learn new techniques and tasks as necessary. • Ability to thrive in a multidisciplinary team environment.
Desirable Requirements • Experience with the ubiquitin-proteasome pathway including monitoring the ubiquitin-proteasome and autophagy system and protein-protein interaction complex dynamics are a plus. • Neuroscience and/or immunology background is a plus. • Understanding of protein biochemistry, recombinant proteins and tagging schemes and protein biophysical characterization.  • Experience with small molecules/ligands/therapeutics in a pharma/biotech environment. • Experience with high throughput screening is desired.


We offer a competitive compensation and benefits package including 401k, health benefits and vacation. As an equal opportunity employer, UCB will consider all qualified applications for employment.  EOE AA M/F/Vet/Disability. Please visit our website:
January 22, 2019

Job Segment: Biochemistry, Neurology, Physiology, Biotech, Immunology, Healthcare, Science

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