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Let's push the boundaries together and make the most of your talents!

Gene Therapy Process Sciences Group Lead

Location: 

Braine L'alleud, Walloon Brabant, Belgium

Job Function:  Clinical Development
Job ID:  66711

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

Gene Therapy Process Sciences Group Leader

 

Location: Braine L'alleud, Walloon Brabant, Belgium

 

To strengthen our Gene Therapy CMC Development Sciences (GTCS) team, based in our hub in Braine, Belgium we are looking for a talented individual to fill the position of: Gene Therapy Process Sciences Group Leader.

 

As a Gene Therapy Process Sciences Group Leader, you will identify and foster purposeful partnerships with key scientific influencers to drive new sources of patient value.

 

You like to work in an environment where you can: 

  • Contribute to UCB’s capabilities and capacities for internal or external development of adeno associated viral vector processes
  • Manage a diverse and dynamic workforce of scientists
  • Lead external and/or internal process development activities for adeno associated viral vectors (AAV)
  • Contribute to determining UCB’s priorities/strategies and guides the AAV drug substance development process
  • Participates in continuous improvements of HSE & quality standards

 

You will contribute by:

  • Demonstrating innovative design, development, and execution of process development projects through literature review and scientific teamwork
  • Developing robust, scalable, transferable processes for upstream production of clinical viral gene therapy material. Also leading process transfer to CMOs and supporting regulatory filings
  • Leading both from the bench (hands-on laboratory work) and from the desk (designing studies, analyzing data, preparing reports and documents)
  • Writing study reports, process characterization reports, and regulatory documents and presenting results at appropriate scientific meetings
  • Authoring specific CMC sections of regulatory filings (including INDs, BLA’s, and formal responses to regulatory inquiries), defining AAV drug substance process control strategies and data integrity
  • Participating in planning to ensure alignment between resource availability and project pipeline
  • Driving innovation from ideation to realization for process improvements, including definition of technology roadmap, justification of projects, and developing implementation plans
  • Building a culture that embraces continuous learning, improvement, and innovation, and encouraging team members to expand their technical skill
  • Leading and supporting research initiatives such as new technology development and continuous improvement projects

 

Interested? For this position you’ll need the following education, experience and skills:

  • PhD (Chemical engineering, Bioengineering, Biology, Biochemistry, Virology, or related field) with 5+ years’ experience or Master with 8+ years’ experience, or Bachelor Degree with 13+ years’ experience in process development of large molecule or cellular therapies
  • Knowledge of viral gene therapy (adeno associated viral vectors preferred); background in protein and/or viral engineering
  • Knowledge and working experience with cell culture process development in mammalian cells, transient transfection, media development, process scale-up, bioreactor design and optimization, and transfection
  • A demonstrated record of scientific expertise (i.e. publications, presentations, etc.)
  • Ability to work with multiple stakeholders to develop strong cross-functional teams
  • Ability to take a proactive approach on the job
  • Excellent communication skills
  • Experience with process characterization and transfer is essential. Expertise in DOE and statistical analysis of data is highly desirable
  • Experience building, leading and managing teams of scientists
  • Ability to work independently and lead others in designing and developing experiments, analyzing and interpreting data in a rigorous way
  • Ability to multi-task and support more than one project simultaneously
  • Understanding and knowledge of key scientific software programs
  • Understanding and knowledge of regulatory requirements for AAV products
  • Strong organizational skills, analytical and problem-solving skills

 

Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.

If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.

 

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

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