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Let's push the boundaries together and make the most of your talents!

Principal Scientist - Medicinal Chemistry


Cambridge, Massachusetts, United States

Job Function:  Research & Early Development
Job ID:  71549

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

We are seeking a talented Principal Scientist – Medicinal Chemistry to join the small molecule medicinal chemistry group located in Cambridge, MA and participate with our multi-disciplinary teams to integrate biological, DMPK and formulation data to accelerate multi-parameter optimization to deliver clinical candidates.


Major Accountabilities/Responsibilities:


  • Conceiving and executing medicinal chemistry initiatives across multiple project phases including hit generation, lead identification and optimization, and ADMET property optimization, all within the context of a target pharmaceutical product profile
  • Analysis of complex data sets and creation of design hypotheses
  • Outstanding leadership, interpersonal, communication, and time-management skills are essential
  • Work with multidisciplinary preclinical development teams to enable the transition from hit to lead candidate as well as final nomination of a clinical candidate


Education and Qualification:


  • MS or PhD in synthetic organic or medicinal chemistry
  • Minimum 7 years of industrial experience in drug discovery and development




  • Previous experience of medicinal chemistry or project leadership preferred
  • Strong written and interpersonal communication skills
  • Ability to communicate effectively and work in a team-based environment
  • Ability to co-ordinate efforts with CROs as well as internal multi-disciplinary teams
  • Demonstrated creativity, inventiveness and innovation in solving problems related to potency, safety and druggability of candidate molecules.
  • Ability to define practical solutions to make go/no-go decisions and effectively communicate program progress within chemistry as well as at larger project team meetings.
  • Experience with structure-based drug design


About us.


UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.


Curious to know more? Please visit our website www.ucb.com.


UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

Job Segment: Chemistry, Organic Chemistry, Scientific, Neurology, Immunology, Science, Engineering, Healthcare

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