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Let's push the boundaries together and make the most of your talents!

Research Scientist/Senior Scientist - Biomarkers

Location: 

Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  71613

Help us transform patients' lives.

 

At UCB, we put our heart, soul and skills into making a difference for people living with severe diseases.  Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in this pioneering adventure? 

 

 

Role overview

 

The Translational Biomarkers and Bioanalysis group is positioned within Development Sciences, which as a division provides strategy and support in integrated pharmacokinetics/pharmacodynamics and DMPK, bioanalysis, immunogenicity, safety, pathology, and regulatory activities throughout the lifespan of projects, from target identification through to clinical studies. The Translational Biomarkers and Bioanalysis department collaborates closely with colleagues in Development Sciences and across the organization to support bioanalysis and biomarker activities.

 

The Immunoassay Group within Translational Biomarkers and Bioanalysis is seeking a Research Scientist/Senior Scientist with proven experience developing scientifically and technically challenging biomarker assays.  As the position will be predominantly laboratory-based the candidate should have a strong scientific and technical background.  Some project team-facing experience would also be an advantage. Key considerations include good organisation and time management skills; effective and proactive communication; positive attitude; ability to multi-task in a fast-paced matrix-team environment.

 

The role is based in Slough, UK. 

 

Primary responsibilities

 

  • Primarily laboratory-based with some interaction with project teams to provide progress updates. 
  • Development, optimisation and fit-for-purpose validation of high-quality biomarker assays.
  • Understanding the scientific question to be answered to help define the assay performance characteristics.
  • Troubleshooting complex scientific/technical challenges in collaboration with other team members/project stakeholders.
  • Act as a subject matter expert, working closely with the Bioanalytical Representative/Bioanalytical Scientific Manager, to successfully transfer methods to contract research organisations (CRO’s).
  • Potential to act as a Bioanalytical Representative on project teams, responsible for implementing and driving the project’s bioanalytical strategy (for the measurement of PK, anti-drug antibodies and biomarkers).
  • Maintain an awareness of new / emerging techniques and tools relevant to the field.
  • Ensure compliance with all health and safety, HTA, other regulations.

 

Essential experience

 

  • The applicant should have a minimum of a BSc (or equivalent) in a biological discipline.
  • A proven track record of developing and validating bespoke biomarker assays using ligand binding assay platforms (e.g. MSD, ELISA, bead-based assays) – including considerations on appropriate reagents and assay format and identifying potential limitations.
  • Proficient in data analysis and appropriate statistical methods.
  • An up to date knowledge of new and emerging technologies for biomarker assays.
  • An appreciation of the importance of understanding the Context of Use and biomarker biology, and translation of this into fit-for-purpose biomarker assay validation.
  • Experience working with multi-disciplinary project teams – e.g. presenting data, progress updates and recommended next steps.
  • Demonstrated ability to multi-task effectively in a dynamic laboratory environment to project timelines with minimal supervision; able to communicate clearly with colleagues; discuss ideas and challenge constructively.
  • Adaptable to changing project and organisational priorities.

 

Preferred

 

  • Previous experience of working in a pharmaceutical drug discovery/development environment.
  • Experience with high sensitivity ligand binding assay platforms (e.g. Quanterix SIMOA, Singulex).
  • Knowledge and awareness of other technology platforms that could be considered for biomarker assay development (e.g. targeted LC-MS, flow cytometry).
  • Experience of developing a bioanalytical strategy in support of a drug discovery programme, considering pharmacokinetic (PK), immunogenicity and pharmacodynamic (PD) aspects.
  • Experience in transfer of analytical methods to Contract Research Organisations.
  • Experience of working with electronic laboratory notebooks.

 

 

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 


Job Segment: Scientific, Neurology, Immunology, Research Scientist, Pathology, Engineering, Healthcare, Science

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