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Let's push the boundaries together and make the most of your talents!

Senior Group Leader - Protein Structure Group


Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  67082

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?


Role overview

The Protein Structure and Biophysics department, within the R&D sector of UCB, comprises 4 sub-groups: Protein Production, Protein Structure, Protein Biophysics and Molecular Spectroscopy.


The Protein Structure Group provides support for projects from early stage mechanistic and structural understanding of new protein targets to contributions in confirming hit identification and cycles of design with CADD and medicinal chemistry groups.


The role is at the Senior Group leader level heading up the Protein Structure group, reporting into the Head of the Protein Structure and Biophysics department.  This is an excellent opportunity to develop the group, driving the scientific direction of the team and maximising the impact of structural biology on drug discovery projects. You will be a high calibre, partly laboratory-based candidate, with extensive experience in protein crystallography, a detailed knowledge of single particle cryo-EM and knowledge of protein NMR.  A key aspect of the role will be to develop members of the team, building a culture of openness and integrity and ensuring operational efficiency.


This role will be based in Slough, UK.



  • Full responsibility for the daily operation of the Protein Structure Team.
  • Ensure all team members are fully engaged and have the opportunity to develop.
  • Hands-on delivery of structural information to support projects.
  • Familiar with all aspects of protein X-ray crystallography of both soluble and membrane proteins.
  • Demonstrate in depth knowledge of software packages and their application to determine structures (CCP4, PHENIX, PyMol, MolProbity; Relion, CCP-EM).
  • Troubleshoot and optimise samples; collaborating with protein biochemists in the Protein Structure and Protein Production groups.
  • Apply knowledge and experience in project meetings to help develop strategy and achieve project goals.
  • Share knowledge and experience across UCB’s structural community.
  • Ensure the Protein Structure team works closely with other functions including CADD, Medicinal Chemistry and Antibody Discovery.
  • Maintain awareness and implement any advances to ensure structural biology at UCB is at the cutting edge at all times.
  • Act as an ambassador for UCB by proactively communicating science externally via oral communications at scientific meetings and through publications in peer reviewed scientific journals.



  • A PhD (or equivalent) with extensive protein crystallography knowledge ideally gained in an industrial setting or from a highly regarded laboratory specializing in Biochemistry/Structural biology.
  • A good understanding of single particle cryo-EM is expected, and hands-on experience is desirable but not essential. In addition, familiarity with NMR methodologies is expected.
  • Proven leadership and management skills with the ability to motivate and develop a team.
  • Good understanding of the drug discovery process (NBEs and/or NCEs) with a proven ability to deliver to demanding timelines.
  • Highly motivated individual with excellent attention to detail and critical data analysis skills.
  • Excellent communication skills with the ability to influence the internal and external environment.
  • Proven track record of publications related to structural biology in peer reviewed, high quality science journals.


About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

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