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Let's push the boundaries together and make the most of your talents!

Senior Scientist - Cryo EM


Slough, Berkshire, United Kingdom

Job Function:  Research & Early Development
Job ID:  69052

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?


Date posted: 5th August 2020


Role Overview

The Protein Structure and Biophysics department, within the R&D sector of UCB, comprises 4 sub-groups: Protein Production, Protein Structure, Protein Biophysics and Molecular Spectroscopy.


The Protein Structure Group provides support for projects from early stage mechanistic and structural understanding of new protein targets to contributions in confirming hit identification and cycles of design with CADD and Medicinal Chemistry groups.


The position offers an opportunity to take a lead role in developing the cryo-EM capabilities of the Structure Group.  You will be a high calibre, laboratory based candidate, with expertise in electron microscopy, who can quickly integrate into this highly motivated and focussed team. You will have a key role in operating an electron microscope, preparation and optimisation of sample grids, expertise in the use of current generation electron microscopes, high-resolution data collection and image processing, as well as knowledge of automated pre-processing pipelines and high-resolution model building.


The position will be based in Slough, UK with occasional travel to Cambridge.


Primary Responsibilities

  • Hands on responsibility for the daily operation of all aspects of cryo-EM within the Protein Structure team.
  • Demonstrate knowledge of software for data collection strategies (for example, EPU) and its application to automated image collection.
  • Be familiar with operational procedures and issues of a new generation electron microscope. Some trouble shooting to maintain a Glacios microscope at peak performance.
  • Flexibility to collect high resolution images at the Consortium Krios instruments, located in Cambridge.
  • Demonstrate in depth knowledge of software packages (for example, Relion and Eman) and their application to analyse cryo-EM image data to determine structure.
  • Troubleshoot and optimise samples; collaborating with protein biochemists in the Protein Structure and Protein Production groups.
  • Actively participate in project meetings applying structural knowledge of targets to help develop strategy and achieve project goals.
  • Share knowledge and experience across UCB’s structural community.
  • Lead the development of novel electron microscopy technology in the Protein Structure team.
  • Act as an ambassador for UCB by proactively communicating science externally via oral communications at scientific meetings and through publications in peer reviewed scientific journals.


Essential Requirements

  • A PhD (or equivalent) with several years’ experience of hands on electron microscopy cryo-EM sample preparation and data analysis, from a highly regarded laboratory in a Biochemistry/Structural Biology environment.
  • Proven track record of publications related to cryo-EM applications in peer reviewed, high quality science journals.
  • Highly motivated individual with excellent attention to detail and critical data analysis skills.
  • Exceptional organisational skills with proven ability to deliver to tight timelines.
  • Flexibility in learning new techniques including biophysical and computational analysis skills.
  • Excellent communication and team-working ability.


We can offer you the opportunity to join a leading biopharmaceutical company.  In return, UCB is offering a competitive salary and benefits package, with continuous profesional and personal development.



About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

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